ABOLISHED KETAMINE EFFECTS ON THE SPONTANEOUS EXCITATORY POSTSYNAPTIC CURRENT OF MEDIAL PREFRONTAL CORTEX NEURONS IN GLUN2D KNOCKOUT MICE

Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice

Abstract Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect.It exerts psychomimetic effects, TIE CLIPS yet demands a further investigation of its mechanism.Previous research showed that ketamine did no longer promote hyperlocomotion in GluN2D knockout (KO) mice, whic

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